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Data Science | DSDHT
Are there any new drugs left?
Boiling the ocean - integrating everything for patient care
Boiling the ocean - integrating everything together
Gene expression data analysis
Information-based Drug Discovery
Introduction to R Shiny
Managing disease with data science
Mapping Structure to function
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Rational Drug Discovery Case Study - Resulin and Avandia
David Wild tells the story of two diabetes drugs, Resulin and Avandia, and one protein target, PPAR-Gamma. A nuanced story about rational drug discovery - a success, in that these drugs constituted a radical new approach to treating type-2 Diabetes, but at a cost, including rare but severe side effects.
Understand at a high level how Resulin and Avandia work
Know the crucial difference between the diseases of diabetes and HIV
Be able to state 2-3 limitations of the rational, reductionist approach
Be able to discuss why these limitations can be a critical problem
Resulin (Troglitazone) Wikipedia page
Avandia (Rosiglitazone) Wikipedia page
The Rise and Fall of Rosiglitazone
(European Heart Journal)
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