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Data Science | DSDHT
Are there any new drugs left?
Boiling the ocean - integrating everything for patient care
Boiling the ocean - integrating everything together
Gene expression data analysis
Information-based Drug Discovery
Introduction to R Shiny
Managing disease with data science
Mapping Structure to function
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Rational drug discovery case study - HIV protease inhibitors
The development of HIV Protease inhibitors, one of the main treatments for HIV and Aids, was one of the great successes of the rational drug discovery approach. In this module, David Wild takes you through the story of HIV Protease inhibitors, how the drugs were designed, and why the rational method worked.
Be able to describe how rational drug discovery accelerated the discovery of HIV treatments
Be able to describe why the rational method worked
Molecules made to measure
, Chemistry World, November 2009 (PDF)
HIV Wikipedia Page
(A77 inhibitor bound to HIV Protease) in the Protein Data Bank
Molecular Docking of an inhibitor into HIV Protease
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