Rational+Drug+Discovery+Case+Study+-+Resulin+and+Avandia

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 * David Wild tells the story of two diabetes drugs, Resulin and Avandia, and one protein target, PPAR-Gamma. A nuanced story about rational drug discovery - a success, in that these drugs constituted a radical new approach to treating type-2 Diabetes, but at a cost, including rare but severe side effects.**


 * Learning Goals**
 * Understand at a high level how Resulin and Avandia work
 * Know the crucial difference between the diseases of diabetes and HIV
 * Be able to state 2-3 limitations of the rational, reductionist approach
 * Be able to discuss why these limitations can be a critical problem


 * Learning Tasks**
 * Read the [|Resulin (Troglitazone) Wikipedia page]
 * Read the [|Avandia (Rosiglitazone) Wikipedia page]


 * Going Deeper**
 * Read [|The Rise and Fall of Rosiglitazone] (European Heart Journal)