Rational+drug+discovery+case+study+-+HIV+protease+inhibitors


 * The development of HIV Protease inhibitors, one of the main treatments for HIV and Aids, was one of the great successes of the rational drug discovery approach. In this module, David Wild takes you through the story of HIV Protease inhibitors, how the drugs were designed, and why the rational method worked.**

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 * Learning Goals**
 * Be able to describe how rational drug discovery accelerated the discovery of HIV treatments
 * Be able to describe why the rational method worked

**Learning Tasks**
 * Read [|Molecules made to measure], Chemistry World, November 2009 (PDF)

**Going Deeper**
 * Read the [|HIV Wikipedia Page]
 * [|Explore 1HVI] (A77 inhibitor bound to HIV Protease) in the Protein Data Bank
 * Watch the [|Molecular Docking of an inhibitor into HIV Protease] (YouTube)