David Wild tells the story of two diabetes drugs, Resulin and Avandia, and one protein target, PPAR-Gamma. A nuanced story about rational drug discovery - a success, in that these drugs constituted a radical new approach to treating type-2 Diabetes, but at a cost, including rare but severe side effects.

Learning Goals
  • Understand at a high level how Resulin and Avandia work
  • Know the crucial difference between the diseases of diabetes and HIV
  • Be able to state 2-3 limitations of the rational, reductionist approach
  • Be able to discuss why these limitations can be a critical problem

Learning Tasks

Going Deeper