In this module, David Wild discusses the major epochs in drug discovery since the first recorded pharmacies in Baghdad around 754. Specifically the long empirical epoch, and the much more recent rational and big experiment (scaled-up rational) epochs. The process by which new drugs are found and developed in the rational approach is described, and students are introduced to some of the concerns that this approach has "run out of steam"

Learning Goals
  • Understand at a high level how drug discovery is done
  • Understand the differences between the empirical, rational and big experiment epochs
  • See the integrative model as one way to understand the future of drug discovery

Learning Tasks

Going Deeper